Description

5-Bromo-2-(Pyrrolidin-3-Yl)Pyridine is a high-value heterocyclic building block featuring a brominated pyridine core fused with a pyrrolidine moiety. This molecular architecture makes it a critical intermediate for medicinal chemistry research and pharmaceutical development, enabling the synthesis of novel bioactive compounds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile bromine handle for cross-coupling reactions.
• Agrochemical Synthesis: Serves as a building block for creating novel active ingredients in crop protection and pesticide formulations.
• Ligand and Catalyst Development: The nitrogen-rich structure is valuable for designing novel chelating ligands and organocatalysts.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Item	Details
Product Name	5-Bromo-2-(Pyrrolidin-3-Yl)Pyridine
CAS No.	1196147-33-7
Molecular Formula	C9H11BrN2
Molecular Weight	227.10 g/mol
Synonyms	5-Bromo-2-(3-pyrrolidinyl)pyridine; 2-(3-Pyrrolidinyl)-5-bromopyridine; 5-Bromo-2-pyrrolidin-3-ylpyridine; 3-(5-Bromopyridin-2-yl)pyrrolidine; 5-Bromo-2-(pyrrolidin-3-yl)pyridine; 1196147-33-7 (CAS); 5-Bromo-2-(3-pyrrolidinyl)pyridine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Pyrrolidin-3-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.