Description

Ethyl 4-Chloro-6-(Trifluoromethyl)Nicotinate is a high-value, multi-functional chemical intermediate designed for advanced synthesis. This compound is critical for researchers and manufacturers requiring precise molecular modifications to develop novel active ingredients. It is primarily utilized in the pharmaceutical and agrochemical industries for the research and development of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronic materials and liquid crystals.
• Chemical Biology: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, high-value compounds under cGMP conditions.

Basic Information

Product Name	Ethyl 4-Chloro-6-(Trifluoromethyl)Nicotinate
CAS No.	1196146-35-6
Molecular Formula	C9H7ClF3NO2
Molecular Weight	253.61 g/mol
Synonyms	Ethyl 4-chloro-6-(trifluoromethyl)pyridine-3-carboxylate; 4-Chloro-6-(trifluoromethyl)nicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 4-chloro-6-(trifluoromethyl)-, ethyl ester; Ethyl 4-chloro-6-trifluoromethylnicotinate; 4-Chloro-6-trifluoromethyl-nicotinic acid ethyl ester; 1196146-35-6
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-6-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support custom synthesis to meet specific purity or impurity profile specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali. Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.