Description

4-Chloro-3-Ethynylpyridine is a high-value, multi-functional pyridine derivative featuring both a halogen and an alkyne functional group. This unique structure makes it a critical pharmaceutical intermediate and a versatile building block for advanced organic synthesis. It is primarily utilized by research institutions and chemical manufacturers in the life sciences sector for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Serves as a building block for developing new crop protection agents and herbicides.
• Material Science: Used in the creation of advanced polymers, ligands for catalysis, and metal-organic frameworks (MOFs) due to its reactive alkyne moiety.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Click Chemistry: The terminal alkyne is ideal for Huisgen 1,3-dipolar cycloaddition (click chemistry) to create triazole-linked compounds for bioconjugation and library synthesis.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.

Basic Information

Product Name	4-Chloro-3-Ethynylpyridine
CAS No.	1196145-03-5
Molecular Formula	C7H4ClN
Molecular Weight	137.57 g/mol
Synonyms	3-Ethynyl-4-chloropyridine; 4-Chloro-3-ethynylpyridine; 4-Chloro-3-pyridylethyne; 3-(4-Chloropyridin-3-yl)ethyne; Pyridine, 4-chloro-3-ethynyl-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Ethynylpyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.