Description

Dabrafenib Mesylate is a potent and selective small-molecule inhibitor of the BRAF V600E kinase, a key target in oncology research and treatment. This compound is critical for the development of targeted cancer therapies, particularly for melanoma and other solid tumors harboring the BRAF V600 mutation. It is an essential active pharmaceutical ingredient (API) and research chemical for pharmaceutical manufacturers, biotechnology companies, and academic research institutions focused on precision medicine and kinase inhibitor development.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of targeted anti-cancer drugs.
• Key reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Critical research tool for in vitro and in vivo studies investigating BRAF V600E-driven oncogenesis.
• Used in preclinical and clinical research to study drug resistance mechanisms and combination therapies.
• Essential component in biochemical assays for high-throughput screening of complementary therapeutic agents.
• Building block for the synthesis of novel drug derivatives and prodrugs in medicinal chemistry programs.

Basic Information

Product Name	Dabrafenib Mesylate
CAS No.	1195768-06-9
Molecular Formula	C23H20F3N5O2S2 • CH4O3S
Molecular Weight	615.66 g/mol
Synonyms	Dabrafenib methanesulfonate; GSK2118436B; N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate; Tafinlar (brand name salt form); BRAF V600E inhibitor; B-RAF kinase inhibitor
EINECS	Contact for details

Quality Control

Our Dabrafenib Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) with detailed batch-specific results are provided and can be tailored to meet specific pharmacopeial (e.g., USP) or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.