Description

Dabrafenib CAS NO 1195765-45-7 is a potent and selective small-molecule inhibitor of the BRAF V600E kinase, a key target in oncology research and development. This compound is critical for advancing targeted cancer therapies, particularly for melanoma and other solid tumors harboring the BRAF V600 mutation. It is an essential active pharmaceutical ingredient (API) and a vital reference standard for pharmaceutical manufacturers, research institutions, and clinical laboratories engaged in the development and quality control of innovative cancer treatments.

Application

• Active Pharmaceutical Ingredient (API) in the commercial manufacturing of targeted anti-cancer therapeutics.
• Reference Standard for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Biochemical Research tool for studying BRAF/MEK/ERK signaling pathways and mechanisms of drug resistance.
• Preclinical Development for in vitro and in vivo efficacy and toxicology studies of novel oncology candidates.
• Formulation Development for creating various dosage forms such as tablets or capsules.
• Combinatorial Therapy Research, particularly in studies combining BRAF inhibitors with MEK inhibitors or immunotherapies.

Basic Information

Product Name	Dabrafenib
CAS No.	1195765-45-7
Molecular Formula	C23H20F3N5O2S2
Molecular Weight	519.56 g/mol
Synonyms	Dabrafenib; GSK2118436; N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; Tafinlar (Trade Name); BRAF V600E Inhibitor; GSK-2118436; (GSK)2118436A
EINECS	Contact for details

Quality Control

Our Dabrafenib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet the stringent requirements for pharmaceutical use. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and heavy metals are available for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.