Description

Fruquintinib|Hmpl-013 is a potent and highly selective small-molecule inhibitor targeting vascular endothelial growth factor receptors (VEGFRs), specifically developed for oncology research and therapeutic applications. This compound matters for its critical role in inhibiting tumor angiogenesis, a key process for cancer growth and metastasis, making it a valuable tool for drug discovery and development. Pharmaceutical researchers, biotechnology companies, and academic institutions focused on developing novel cancer treatments are the primary users of this high-purity reference standard.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for quality control and analytical method development in the production of fruquintinib-based therapeutics.
• Oncology Research & Drug Discovery: Used in in vitro and in vivo studies to investigate VEGFR inhibition, anti-angiogenic effects, and potential anti-tumor activity.
• Preclinical Development: Essential for pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies during the development of new anti-cancer drugs.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzyme inhibition assays to study kinase selectivity and potency.
• Academic Research: Supports fundamental research into angiogenesis signaling pathways and cancer biology at universities and research institutes.
• Formulation Development: Used in the development and testing of various drug delivery systems for fruquintinib.

Basic Information

Item	Details
Product Name	Fruquintinib
CAS No.	1194506-26-7
Molecular Formula	C₂₁H₁₉FN₄O₅
Molecular Weight	426.40 g/mol
Synonyms	Fruquintinib; HMPL-013; 6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,4-dimethyl-5-[(2,2,2-trifluoroacetyl)amino]-2-pyridinecarboxamide; Elunate (Brand Name); VEGFR Inhibitor; TKI Fruquintinib; Apatinib analogue; Kinase Inhibitor 013
EINECS	Contact for details

Quality Control

Our Fruquintinib|Hmpl-013 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.