Description

5-Azido-2'-Deoxycytidine is a chemically modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. This compound matters for its role as a versatile click chemistry reagent, enabling the precise labeling and study of nucleic acids and other biomolecules. It is primarily needed by researchers and manufacturers in the fields of nucleoside chemistry, medicinal chemistry, and bioconjugation, particularly for developing probes, diagnostics, and targeted therapeutics.

Application

• Click Chemistry Reagent: Used for bioorthogonal labeling of DNA and RNA strands via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Nucleoside Analogue Synthesis: Serves as a critical precursor for synthesizing novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Bioconjugation & Probe Development: Enables the attachment of fluorophores, affinity tags, or other functional groups to nucleic acids for imaging and detection applications.
• Medicinal Chemistry Research: Investigated for incorporation into oligonucleotides to create modified aptamers or siRNA with enhanced stability or targeting properties.
• Chemical Biology Studies: Utilized to study DNA-protein interactions, replication, and repair mechanisms through site-specific incorporation.
• Pharmaceutical Intermediate: Acts as a specialized intermediate in the research and development stages of novel therapeutic agents.

Basic Information

Item	Details
Product Name	5-Azido-2'-Deoxycytidine
CAS No.	1193451-72-7
Molecular Formula	C9H12N6O4
Molecular Weight	268.23 g/mol
Synonyms	5-Azido-2'-deoxycytidine; 5-Azidodeoxycytidine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2-dihydropyrimidin-2-one 5-azide; 5-N3-dC; Azidodeoxycytidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-amino-5-azido-2(1H)-pyrimidinone; 5-Azido-1-(2-deoxy-β-D-ribofuranosyl)cytosine
EINECS	Contact for details

Quality Control

Our 5-Azido-2'-Deoxycytidine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.