Description

2-(Difluoromethoxy)-5-Nitropyridine is a specialized fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a valuable intermediate for constructing complex molecules with tailored electronic and physical properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the nitropyridine core can be functionalized to create potent bioactive compounds.
• Material Science: Serves as a monomer or functional additive in the synthesis of specialty polymers, liquid crystals, and electronic materials that benefit from its aromatic and electron-deficient character.
• Chemical Synthesis: A versatile reagent for constructing complex heterocyclic systems, enabling nucleophilic aromatic substitution and cross-coupling reactions in medicinal chemistry.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Nitropyridine
CAS No.	1192813-41-4
Molecular Formula	C6H4F2N2O3
Molecular Weight	190.10 g/mol
Synonyms	5-Nitro-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-nitropyridine; 5-Nitro-2-(difluoromethoxy)pyridine; Pyridine, 2-(difluoromethoxy)-5-nitro-; 1192813-41-4
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-5-Nitropyridine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.