Description

2-Bromo-3'-Chloro-2'-Fluoroacetophenone is a high-purity, multi-halogenated acetophenone derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors or other halogen-sensitive pharmacophores.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the halogen atoms contribute to biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of functional polymers and advanced catalytic systems.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A crucial starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-Bromo-3'-Chloro-2'-Fluoroacetophenone
CAS No.	1192313-64-6
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	1-(3-Chloro-2-fluorophenyl)-2-bromoethan-1-one; 2-Bromo-1-(3-chloro-2-fluorophenyl)ethanone; α-Bromo-3-chloro-2-fluoroacetophenone; 3'-Chloro-2'-fluoro-2-bromoacetophenone; 2-Bromo-3-chloro-2-fluoroacetophenone; Ethanone, 2-bromo-1-(3-chloro-2-fluorophenyl)-; (3-Chloro-2-fluorophenyl)(bromo)methanone (tautomeric form)
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3'-Chloro-2'-Fluoroacetophenone is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.