Description

4-[2-(Trimethylsilyl)Ethynyl]-1H-Indole-2,3-Dione is a specialized, high-value synthetic intermediate featuring a unique molecular architecture that combines an isatin core with a trimethylsilyl-protected acetylene moiety. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the construction of complex heterocyclic systems and functionalized molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for drug discovery programs and the development of novel functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new active ingredients for crop protection with potential novel modes of action.
• Material Science: Acts as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the study of biological pathways.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry, including cross-coupling and cyclization reactions.

Basic Information

Product Name	4-[2-(Trimethylsilyl)Ethynyl]-1H-Indole-2,3-Dione
CAS No.	1192263-95-8
Molecular Formula	C₁₄H₁₅NO₂Si
Molecular Weight	257.36 g/mol
Synonyms	4-[(Trimethylsilyl)ethynyl]isatin; 4-(2-Trimethylsilylethynyl)indoline-2,3-dione; 4-(Trimethylsilylethynyl)-1H-indole-2,3-dione; 4-Ethynyl-1H-indole-2,3-dione trimethylsilyl ether; TMS-Ethynyl Isatin; 4-(Trimethylsilylethynyl)isatin
EINECS	Contact for details

Quality Control

Our 4-[2-(Trimethylsilyl)Ethynyl]-1H-Indole-2,3-Dione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency essential for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.