Description

(S)-n-Fmoc-2-(6'-Azido)Alanine CAS NO 1191429-14-7 is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and bioconjugation. This compound is critically important for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the site-specific introduction of azide functional groups into peptide chains for subsequent 'click chemistry' reactions. It is primarily needed by organizations engaged in the development of peptide-based therapeutics, diagnostic probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating azido handles into custom peptide sequences.
• Bioconjugation & Labeling: Enables efficient, chemoselective coupling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-tagged fluorophores, biotin, or other molecules.
• Antibody-Drug Conjugate (ADC) Development: Used to create linker-payload constructs with precise, stable attachment sites.
• Chemical Biology Probes: Facilitates the study of protein-protein interactions and cellular localization through bioorthogonal labeling strategies.
• Material Science: Serves as a monomer for creating functionalized polymers and surfaces with bioactive properties.
• Library Synthesis: Essential for generating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(S)-n-Fmoc-2-(6'-Azido)Alanine
CAS No.	1191429-14-7
Molecular Formula	C18H16N4O4
Molecular Weight	352.35 g/mol
Synonyms	Fmoc-Azidoalanine-OH; Fmoc-6-Azido-L-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-azido-L-norleucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-6-azidohexanoic acid; Fmoc-Lys(N3)-OH (common abbreviation); Fmoc-6-Azido-L-lysine; Nα-Fmoc-Nε-azido-L-lysine
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-2-(6'-Azido)Alanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates or advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For short-term use (up to one month), storage at 2-8°C in a desiccator is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.