Description

Fluorobexarotene CAS NO 1190848-23-7 is a synthetic retinoid analog, specifically a fluorinated derivative of bexarotene, designed for enhanced stability and targeted pharmacological activity. This compound is of significant interest for advanced research and development in oncology and dermatology due to its potential to modulate retinoid X receptor (RXR) pathways. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in the discovery of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical high-purity standard for analytical method development, validation, and quality control in drug substance manufacturing.
• Oncology Research: Investigated as a potential active pharmaceutical ingredient (API) or intermediate in the development of novel cancer therapies, particularly for cutaneous T-cell lymphoma and other malignancies.
• Dermatological Drug Discovery: Used in preclinical studies targeting skin disorders where RXR modulation is a therapeutic strategy.
• Biochemical Research: Employed as a selective ligand to study RXR receptor function, gene expression, and signaling pathways in cellular and molecular biology.
• Process Chemistry & Intermediate: Acts as a key fluorinated synthetic intermediate for the preparation of more complex retinoid-based drug candidates.

Basic Information

Product Name	Fluorobexarotene
CAS No.	1190848-23-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid Fluorinated Derivative; Fluorinated Bexarotene; Bexarotene Fluorinated Analog; RXR Agonist Fluorinated Derivative; Targretin Fluorinated Analog
EINECS	Contact for details

Quality Control

Our Fluorobexarotene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.