Description

(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-9-[[Tris(1-Methylethyl)Silyl]Oxy]-5H-Cyclohepta[B]Pyridin-5-One CAS NO 1190363-46-2 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protective silyl ether group. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its defined chiral centers are essential for biological activity. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors engaged in developing novel therapeutic agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial chiral precursor in multi-step synthetic routes for novel drug candidates.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in developing and optimizing scalable manufacturing processes for APIs under GMP conditions.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs for the production of clinical trial materials and commercial drug substances.
• Synthesis of Biologically Active Molecules: Utilized in constructing complex heterocyclic frameworks with potential activity in central nervous system (CNS), anti-inflammatory, or oncological targets.

Basic Information

Product Name	(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-9-[[Tris(1-Methylethyl)Silyl]Oxy]-5H-Cyclohepta[B]Pyridin-5-One
CAS No.	1190363-46-2
Molecular Formula	C26H33F2NO2Si
Molecular Weight	457.64 g/mol
Synonyms	(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[(triisopropylsilyl)oxy]-5H-cyclohepta[b]pyridin-5-one; 9-[(Triisopropylsilyl)oxy]-(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one; TIPS-protected cycloheptapyridinone derivative; CAS 1190363-46-2; 5H-Cyclohepta[b]pyridin-5-one, 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-, (6S,9R)-; Advanced Pharmaceutical Intermediate 1190363-46-2.
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Quality Control

Our (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-Tetrahydro-9-[[Tris(1-Methylethyl)Silyl]Oxy]-5H-Cyclohepta[B]Pyridin-5-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure storage areas are free from such contaminants. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.