Description

3-Iodo-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block featuring both iodine and trifluoromethyl substituents. This compound is critical for medicinal chemistry and agrochemical research, enabling the synthesis of novel bioactive molecules through cross-coupling reactions and structural diversification. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing targeted therapies and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting oncology and CNS diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the biological activity of the pyrrolopyridine core and the metabolic stability imparted by the trifluoromethyl group.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a molecular probe or tag in bioconjugation and labeling studies, utilizing the reactive iodine handle for further functionalization.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to create complex molecular architectures.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery campaigns.

Basic Information

Product Name	3-Iodo-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1190320-87-6
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	3-Iodo-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 6-(Trifluoromethyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-6-(trifluoromethyl)-; 3-Iodo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-6-(trifluoromethyl)-7-azaindole
EINECS	Contact for details

Quality Control

Our 3-Iodo-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.