Description

3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-5-Carboxylic Acid is a high-value brominated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its unique fused pyrrolopyridine scaffold, functionalized with both a bromine atom and a carboxylic acid group, makes it a versatile intermediate for constructing complex molecules via cross-coupling and amide bond formation. This compound is primarily utilized by medicinal chemists and process development scientists in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting challenging biological pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a precursor for functionalized organic semiconductors and ligands for catalytic systems.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing custom APIs and advanced intermediates under cGMP conditions.

Basic Information

Product Name	3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-5-Carboxylic Acid
CAS No.	1190317-33-9
Molecular Formula	C8H5BrN2O2
Molecular Weight	241.04 g/mol
Synonyms	3-Bromo-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid; 5-Bromo-7-azaindole-3-carboxylic acid; 3-Bromo-7-azaindole-5-carboxylic acid; 1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid, 3-bromo-; 3-Bromo-1H-pyrrolo[3,2-b]pyridin-5-carboxylic acid; 3-Bromo-5-carboxy-7-azaindole
EINECS	Contact for details

Quality Control

Our 3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. For advanced applications, we offer development and production under cGMP guidelines to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.