Description

1H-Pyrrolo[3,2-B]Pyridine, 5-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the fused pyrrolopyridine scaffold and the strategically positioned trifluoromethyl group, which are critical for modulating the physicochemical profiles of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology, CNS disorders, and antiviral therapies.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a building block for creating specialized organic electronic materials and functional polymers.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library production.

Basic Information

Product Name	1H-Pyrrolo[3,2-B]Pyridine, 5-(Trifluoromethyl)-
CAS No.	1190315-94-6
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	5-(Trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine; 5-(Trifluoromethyl)-7-azaindole; 5-Trifluoromethyl-1H-pyrrolo[3,2-b]pyridine; 1H-Pyrrolo[3,2-b]pyridine, 5-(trifluoromethyl)-; 5-CF3-7-azaindole; 5-(Trifluoromethyl)-7-aza-indole; 7-Azaindole, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[3,2-B]Pyridine, 5-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong alkali and fluorides; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.