Description

1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-, Methyl Ester is a high-purity heterocyclic building block essential for advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for constructing complex molecular architectures, particularly in kinase inhibitor programs. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery campaigns.
• Agrochemical Development: Serves as a building block for novel active ingredients in crop protection products.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry: Employed in route scouting and scale-up synthesis for Active Pharmaceutical Ingredient (API) manufacturing.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-, Methyl Ester
CAS No.	1190312-37-8
Molecular Formula	C9H7ClN2O2
Molecular Weight	210.62 g/mol
Synonyms	6-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; Methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 6-Chloro-4-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine; 6-Chloro-1H-pyrrolo[2,3-b]pyridine-4-methyl carboxylate; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, methyl ester; 6-Chloro-4-carbomethoxy-1H-pyrrolo[2,3-b]pyridine; 6-Chloro-1H-7-azaindole-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.