Description

3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-6-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its unique fused pyrrolopyridine scaffold, functionalized with both bromo and cyano groups, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by medicinal chemists and process development scientists in the life sciences sector for the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient π-system.
• Chemical Biology: Employed as a molecular probe or a tag in bioconjugation chemistry and proteomics research.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Nucleophilic Substitution & Cyano Group Transformation: The cyano group can be hydrolyzed to amides or acids, reduced to amines, or serve as a nitrile oxide precursor in cycloaddition reactions.

Basic Information

Product Name	3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-6-Carbonitrile
CAS No.	1190311-98-8
Molecular Formula	C8H4BrN3
Molecular Weight	222.04 g/mol
Synonyms	3-Bromo-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile; 6-Cyano-3-bromo-1H-pyrrolo[3,2-b]pyridine; 3-Bromo-6-cyanopyrrolo[3,2-b]pyridine; 1H-Pyrrolo[3,2-b]pyridine-6-carbonitrile, 3-bromo-; 3-Bromo-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile (CAS 1190311-98-8)
EINECS	Contact for details

Quality Control

Our 3-Bromo-1H-Pyrrolo[3,2-B]Pyridine-6-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.