Description

3-Bromo-6-Trifluoromethyl-4-Azaindole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromo-substituent for further functionalization and a trifluoromethyl group, which is highly sought after for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex nitrogen-containing heterocycles, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant scaffolds.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse molecular libraries.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on molecular conformation, binding affinity, and bioavailability.

Basic Information

Product Name	3-Bromo-6-Trifluoromethyl-4-Azaindole
CAS No.	1190311-58-0
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	3-Bromo-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-6-(trifluoromethyl)-7-azaindole; 6-Trifluoromethyl-3-bromo-4-azaindole; 3-Bromo-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-Trifluoromethyl-4-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.