Description

Ethyl 1-Benzyl-6-Bromo-4-Hydroxy-2-Oxo-1,2-Dihydro[1,8]Naphthyridine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1190198-34-5. This compound is a key synthetic building block valued for its complex heterocyclic structure, which is integral to the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of new therapeutic agents, particularly in oncology and anti-infective research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Used in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) for pre-clinical and clinical trials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	Ethyl 1-Benzyl-6-Bromo-4-Hydroxy-2-Oxo-1,2-Dihydro[1,8]Naphthyridine-3-Carboxylate
CAS No.	1190198-34-5
Molecular Formula	C₁₈H₁₅BrN₂O₄
Molecular Weight	403.23 g/mol
Synonyms	1,2-Dihydro-1-benzyl-6-bromo-4-hydroxy-2-oxo[1,8]naphthyridine-3-carboxylic Acid Ethyl Ester; Ethyl 1-Benzyl-6-bromo-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate; 1-Benzyl-6-bromo-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic Acid Ethyl Ester; 6-Bromo-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester; 1190198-34-5; BRN 12507219
EINECS	Contact for details

Quality Control

Our Ethyl 1-Benzyl-6-Bromo-4-Hydroxy-2-Oxo-1,2-Dihydro[1,8]Naphthyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.