Description

5-Fluoro-1-Benzothiophene-2-Carbonyl Chloride is a high-purity, reactive organic intermediate essential for advanced chemical synthesis. This compound is a critical building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for its role in introducing the benzothiophene scaffold with a reactive acid chloride handle.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides that require the benzothiophene core for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of organic semiconductors, liquid crystals, and advanced polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	5-Fluoro-1-Benzothiophene-2-Carbonyl Chloride
CAS No.	1190198-22-1
Molecular Formula	C9H4ClFOS
Molecular Weight	214.64 g/mol
Synonyms	5-Fluorobenzo[b]thiophene-2-carbonyl chloride; 1-Benzothiophene-2-carbonyl chloride, 5-fluoro-; 5-Fluoro-1-benzothiophene-2-carboxylic acid chloride; 5-Fluorobenzo[b]thiophene-2-carboxylic acid chloride; 2-Carbonyl chloride-5-fluorobenzothiophene; 5-F-BT-COCl
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-1-Benzothiophene-2-Carbonyl Chloride is manufactured under strict quality management protocols. We ensure compliance with cGMP (current Good Manufacturing Practice) standards where applicable for pharmaceutical intermediates. Our rigorous quality testing includes identity confirmation, purity assay, and impurity profiling using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.