Description

Ethyl 2-(Benzylamino)-5-Iodonicotinate is a high-value, functionalized nicotinate derivative serving as a critical synthetic intermediate. This compound is essential for constructing complex molecular architectures, particularly in advanced pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and custom synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile iodo and benzylamino functional groups.
• Agrochemical Synthesis: Intermediate in the development of new generation pesticides and herbicides with specific mode-of-action profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory organic synthesis.

Basic Information

Product Name	Ethyl 2-(Benzylamino)-5-Iodonicotinate
CAS No.	1190198-19-6
Molecular Formula	C15H15IN2O2
Molecular Weight	382.20 g/mol
Synonyms	5-Iodo-2-(benzylamino)nicotinic acid ethyl ester; Ethyl 5-iodo-2-(phenylmethylamino)-3-pyridinecarboxylate; 2-(Benzylamino)-5-iodonicotinic Acid Ethyl Ester; Ethyl 2-(Benzylamino)-5-iodopyridine-3-carboxylate; 1190198-19-6; AI3-63599; SCHEMBL21806627; ZINC000253899977
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Benzylamino)-5-Iodonicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay (HPLC), related substances, and residual solvents. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.