Description

1H-Pyrazole-4-Carboxylic Acid, 3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-, Ethyl Ester is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique pyrazole core and iodine substituent enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole moiety.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Acts as a building block for advanced organic electronic materials and metal-organic frameworks (MOFs) due to its functionalized heterocyclic structure.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Medicinal Chemistry SAR Studies: Utilized to explore structure-activity relationships (SAR) by systematically modifying the ester and THP-protected amine functionalities.

Basic Information

Product Name	1H-Pyrazole-4-Carboxylic Acid, 3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-, Ethyl Ester
CAS No.	1190060-37-7
Molecular Formula	C11H15IN2O3
Molecular Weight	350.16 g/mol
Synonyms	Ethyl 3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylate; 3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(THP)-3-Iodo-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(Tetrahydropyran-2-yl)-3-iodopyrazole-4-carboxylic Acid Ethyl Ester; 3-Iodo-1-(2-tetrahydropyranyl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1H-Pyrazole-4-carboxylic acid, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-, ethyl ester; 1190060-37-7
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-4-Carboxylic Acid, 3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.