Description

Hydroflumethiazide is a potent diuretic and antihypertensive agent belonging to the thiazide class of pharmaceuticals. Its primary value lies in its ability to effectively manage fluid retention and high blood pressure, making it a critical active pharmaceutical ingredient (API) in the formulation of prescription medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing cardiovascular and renal therapeutics. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of hypertension (high blood pressure).
• Edema Management: Formulation into diuretic drugs used to reduce fluid retention (edema) associated with conditions such as congestive heart failure, liver cirrhosis, and renal disorders.
• Cardiovascular Drug Development: Key intermediate or reference standard in the research and development of new cardiovascular therapies.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of branded hydroflumethiazide medications.
• Clinical Research: Utilization as a calibrated standard in pharmacokinetic, pharmacodynamic, and bioequivalence studies.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing fluid balance in animals.

Basic Information

Product Name	Hydroflumethiazide
CAS No.	1189877-11-9
Molecular Formula	C8H8F3N3O4S2
Molecular Weight	331.29 g/mol
Synonyms	3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Saluron; Diucardin; Nefrolan; Hydroflumethiazidum; Flumethiazide derivative; Benzothiadiazine sulfonamide diuretic
EINECS	Contact for details

Quality Control

Our Hydroflumethiazide is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, with specifications aligned with major pharmacopoeial standards. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation due to absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.