Description

5'-Deoxy-5'-Hydrazinylguanosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is specifically engineered to introduce a reactive hydrazinyl group at the 5'-position of the guanosine scaffold, enabling its use in targeted conjugation and synthesis. It is primarily utilized by researchers and manufacturers in the fields of nucleoside-based drug discovery, probe development, and the synthesis of novel oligonucleotide conjugates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Bioconjugation Reagent: The hydrazinyl group serves as a reactive handle for coupling with aldehydes and ketones to create labeled probes or drug-targeting molecules.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research into RNA/DNA structure, function, and therapeutic applications.
• Chemical Biology Research: Enables the study of nucleic acid interactions and the development of activity-based probes for enzyme studies.
• API Development: Serves as a building block in the research and development of Active Pharmaceutical Ingredients (APIs) for targeted therapies.

Basic Information

Product Name	5'-Deoxy-5'-Hydrazinylguanosine
CAS No.	1189743-60-9
Molecular Formula	C10H15N7O4
Molecular Weight	297.27 g/mol
Synonyms	5'-Hydrazinyl-5'-deoxyguanosine; 5'-Deoxy-5'-hydrazineguanosine; Guanosine, 5'-deoxy-5'-hydrazinyl-; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydrazinylmethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-Hydrazinylguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets high-purity research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.