Description

3-(4-Amino-Piperidin-1-Yl)-1-(6-Chloro-Pyridin-3-Yl)-Propan-1-One CAS NO 1189431-89-7 is a high-purity, advanced pharmaceutical intermediate featuring a piperidine-pyridine core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific receptor targeting. It is primarily sought by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of new drug candidates, especially for central nervous system (CNS) and anti-infective therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperidine and chloropyridine moieties.
• API Synthesis: Serves as a building block in multi-step synthesis routes for potential active pharmaceutical ingredients.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and pharmacological studies.
• Agrochemical Intermediate: May find application in the research and synthesis of advanced crop protection agents.

Basic Information

Product Name	3-(4-Amino-Piperidin-1-Yl)-1-(6-Chloro-Pyridin-3-Yl)-Propan-1-One
CAS No.	1189431-89-7
Molecular Formula	C13H18ClN3O
Molecular Weight	267.76 g/mol
Synonyms	1-(6-Chloro-3-pyridinyl)-3-(4-amino-1-piperidinyl)-1-propanone; 3-(4-Aminopiperidin-1-yl)-1-(6-chloropyridin-3-yl)propan-1-one; 1189431-89-7; 1-Propanone, 3-(4-amino-1-piperidinyl)-1-(6-chloro-3-pyridinyl)-; AKOS025247315; 3-(4-Amino-piperidin-1-yl)-1-(6-chloro-pyridin-3-yl)-propan-1-one; 1-(6-Chloropyridin-3-yl)-3-(4-aminopiperidin-1-yl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3-(4-Amino-Piperidin-1-Yl)-1-(6-Chloro-Pyridin-3-Yl)-Propan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.