Description

6-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-(Trimethylsilyl)Furo[3,2-B]Pyrid is a high-value, multi-functionalized heterocyclic compound featuring both tert-butyldimethylsilyl (TBDMS) and trimethylsilyl (TMS) protecting groups. This compound matters as a critical advanced pharmaceutical intermediate or building block for medicinal chemistry research, enabling the synthesis of complex molecules with precise stereochemistry and functional group compatibility. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its derivatizable pyrrolidine and silyl-protected functionalities.
• Agrochemical Synthesis: Employed in the development of novel, high-performance crop protection agents and pesticides.
• Chemical Biology Probe Development: Utilized to create tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Acts as a starting material or intermediate in the pilot and commercial-scale synthesis of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	6-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-(Trimethylsilyl)Furo[3,2-B]Pyrid
CAS No.	1188993-09-0
Molecular Formula	C22H40N2O2Si2
Molecular Weight	420.74 g/mol
Synonyms	2-(Trimethylsilyl)-6-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]methyl]furo[3,2-b]pyridine; 6-((3-((tert-Butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2-(trimethylsilyl)furo[3,2-b]pyridine; TBDMS-protected furopyridine derivative; Silylated furo[3,2-b]pyridine intermediate; 1188993-09-0; 6-[[3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]methyl]-2-(trimethylsilyl)furo[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-(Trimethylsilyl)Furo[3,2-B]Pyrid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.