Description

5-Bromo-2'-Deoxy-2'-Fluoro-3',5'-Di-o-Acetyl Uridine is a high-purity, modified nucleoside building block critical for advanced pharmaceutical research and development. This compound serves as a key synthetic intermediate in the production of oligonucleotides, particularly for antisense and siRNA therapeutics, where precise chemical modification is essential for stability and efficacy. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the development of novel antiviral agents and targeted genetic medicines.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific mRNA sequences.
• siRNA (Small Interfering RNA) Manufacturing: Incorporated into siRNA duplexes to enhance nuclease resistance and improve pharmacokinetic properties.
• Antiviral Drug Research: Serves as a building block in the synthesis of nucleoside analogs investigated for their activity against viral infections.
• Medicinal Chemistry & Lead Optimization: Employed to introduce specific bromo and fluoro modifications into nucleoside scaffolds to study structure-activity relationships (SAR).
• Diagnostic Probe Development: Can be used in the creation of labeled probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	5-Bromo-2'-Deoxy-2'-Fluoro-3',5'-Di-o-Acetyl Uridine
CAS No.	1188522-91-9
Molecular Formula	C₁₃H₁₄BrFN₂O₇
Molecular Weight	409.16 g/mol
Synonyms	5-Bromo-2'-deoxy-2'-fluorouridine 3',5'-diacetate; 2'-Fluoro-5-bromo-2'-deoxyuridine 3',5'-di-O-acetate; 1-[(2R,3R,4R,5R)-3-Acetoxy-5-(acetoxymethyl)-4-fluorooxolan-2-yl]-5-bromopyrimidine-2,4-dione; 5-Br-2'-F-3',5'-di-OAc-Urd; 5-Bromo-2'-fluoro-2'-deoxyuridine 3',5'-diacetate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2'-Deoxy-2'-Fluoro-3',5'-Di-o-Acetyl Uridine is manufactured under strict quality systems to ensure consistency and reliability for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity standards suitable for pharmaceutical research, with typical purity levels exceeding 98% (by HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.