Description

3',5'-Di-o-Acetyl-5-Bromo-2'-o-Methyluridine is a high-purity, chemically modified nucleoside derivative, serving as a critical building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers developing novel therapeutic agents, diagnostic probes, and advanced biochemical tools. It is primarily utilized in the pharmaceutical, biotechnology, and life sciences research sectors for the synthesis of modified RNA and DNA analogs.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate brominated uridine analogs into oligonucleotides for stability and target-binding studies.
• Medicinal Chemistry Research: Serves as an intermediate in the development of nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Probe Development: Enables the creation of labeled or cross-linking nucleotides for studying nucleic acid structure and function.
• Academic & Industrial R&D: A valuable reagent for exploring novel nucleic acid chemistries and enzymatic mechanisms.

Basic Information

Product Name	3',5'-Di-o-Acetyl-5-Bromo-2'-o-Methyluridine
CAS No.	1188522-81-7
Molecular Formula	C14H17BrN2O8
Molecular Weight	421.20 g/mol
Synonyms	5-Bromo-2'-O-methyluridine 3',5'-diacetate; 5-Br-2'-O-Me-uridine 3',5'-diacetate; 2'-O-Methyl-5-bromouridine 3',5'-diacetate; 5-Bromo-2'-O-methyl-3',5'-di-O-acetyluridine; 1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(acetoxymethyl)-3-methyloxolan-2-yl]-5-bromopyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-5-Bromo-2'-o-Methyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.