Description

1-[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Pyrrolidine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific pharmacophores into their target structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the pyridine and trifluoromethyl motifs for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Research: Employed as a molecular probe or scaffold in the study of enzyme inhibition and protein-ligand interactions.
• Material Science: Potential monomer or additive for creating polymers with specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Pyrrolidine-2-Carboxylic Acid
CAS No.	1188435-80-4
Molecular Formula	C11H8ClF3N2O2
Molecular Weight	292.64 g/mol
Synonyms	2-Pyrrolidinecarboxylic acid, 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-; 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrrolidine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-, 2-pyrrolidinyl ester (related); (3-Chloro-5-trifluoromethyl-pyridin-2-yl)-pyrrolidine-2-carboxylic acid; L-Proline, 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-; 1188435-80-4; CAS 1188435-80-4
EINECS	Contact for details

Quality Control

Our 1-[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.