Description

(-)-Emtricitabine Triphosphate Tetrasodium Salt is a high-purity, phosphorylated nucleoside analog crucial for advanced biochemical and pharmaceutical research. This compound serves as a key active metabolite and biochemical tool for studying antiviral mechanisms, particularly those involving reverse transcriptase inhibition. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise, high-quality intermediates for drug development, enzymatic studies, and assay standardization.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis and development of next-generation antiviral medications, particularly nucleoside reverse transcriptase inhibitors (NRTIs).
• Biochemical Research: Used as a substrate or reference standard in enzymatic assays to study the kinetics and inhibition of viral polymerases like HIV-1 reverse transcriptase.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the activation and mechanism of action of prodrugs like emtricitabine.
• Diagnostic Development: Serves as a key component in the development of high-sensitivity diagnostic kits and assays for antiviral drug monitoring and resistance testing.
• Reference Standard: Provides a certified standard for quality control and analytical method validation in pharmaceutical manufacturing and regulatory compliance.

Basic Information

Product Name	(-)-Emtricitabine Triphosphate Tetrasodium Salt
CAS No.	1188407-46-6
Molecular Formula	C9H13FN3Na4O9P3 (or appropriate hydrate form)
Molecular Weight	Contact for details
Synonyms	FTC-TP Tetrasodium Salt; Emtricitabine 5'-Triphosphate Tetrasodium; (-)-FTC-TP Na4; 5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine triphosphate tetrasodium salt; 2'-Deoxy-5-fluoro-3'-thiacytidine 5'-triphosphate tetrasodium salt; Coviracil triphosphate tetrasodium salt; GS-1278 triphosphate tetrasodium salt
EINECS	Contact for details

Quality Control

Our (-)-Emtricitabine Triphosphate Tetrasodium Salt is manufactured under strict quality systems suitable for research and pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your specifications. Quality standards align with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
pH (in solution)	6.0 - 8.0
Residual Solvents (GC)	Meets ICH limits
Biological Activity	Confirmed in enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.