Description

3-Amino-4-Fluorobenzoyl Chloride is a high-purity, reactive aromatic intermediate of significant importance in advanced organic synthesis. Its core value lies in its bifunctional nature, combining a reactive acid chloride group with a protected amino group, making it a versatile building block for constructing complex molecular architectures. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated benzamide or anilide motifs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the fluorine atom and benzoyl chloride group enhance biological activity and stability.
• Peptide Mimetics & Linker Chemistry: Serves as a coupling agent or a building block for creating peptide analogs and bioconjugation linkers in medicinal chemistry and biochemical research.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of fluorinated aromatic cores for advanced electronic and display materials.
• Polymer Modification: Acts as a functional monomer or grafting agent to introduce fluorinated aromatic amide groups into polymer chains, modifying thermal and chemical resistance.
• Dye & Pigment Intermediate: Utilized in the production of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Item	Details
Product Name	3-Amino-4-Fluorobenzoyl Chloride
CAS No.	1187963-65-0
Molecular Formula	C7H5ClFNO
Molecular Weight	173.57 g/mol
Synonyms	4-Fluoro-3-aminobenzoyl chloride; 3-Amino-4-fluorobenzoic acid chloride; 4-Fluoro-m-aminobenzoyl chloride; 3-Amino-4-fluorobenzoic acid chloride; 3-Amino-4-fluorobenzoylchloride; 4-Fluoro-3-aminobenzoic acid chloride; m-Amino-p-fluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-4-Fluorobenzoyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.