Description

tert-Butyl Hexahydro-1H-Pyrrolo[3,4-C]Pyridine-5(6H)-Carboxylate Hydrochloride is a high-purity, protected heterocyclic amine building block essential for advanced pharmaceutical synthesis. This compound matters because it serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing complex molecular scaffolds, enabling the creation of next-generation therapeutics with improved efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies.
• API Development: Serves as a protected precursor in the final stages of Active Pharmaceutical Ingredient (API) manufacturing for clinical trials and commercial production.
• Peptidomimetic Synthesis: Employed in the design and synthesis of peptide analogs and mimetics due to its constrained bicyclic structure.
• Ligand and Catalyst Preparation: Useful for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl Hexahydro-1H-Pyrrolo[3,4-C]Pyridine-5(6H)-Carboxylate Hydrochloride
CAS No.	1187933-06-7
Molecular Formula	C13H24N2O2·HCl
Molecular Weight	276.80 g/mol (Free base: 240.34 g/mol)
Synonyms	tert-Butyl 1,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Hydrochloride; 1-Boc-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid Hydrochloride (incorrect but common misnomer); 5-tert-Butoxycarbonyl-2,3,3a,4,5,6-hexahydro-1H-pyrrolo[3,4-c]pyridine Hydrochloride; 1,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylic Acid, 1,1-Dimethylethyl Ester, Hydrochloride; tert-Butyl Hexahydro-1H-Pyrrolo[3,4-C]Pyridine-5-Carboxylate HCl; Boc-Protected 3-Azabicyclo[3.1.0]hexane Hydrochloride Salt; CAS 1187933-06-7
EINECS	Contact for details

Quality Control

Our tert-Butyl Hexahydro-1H-Pyrrolo[3,4-C]Pyridine-5(6H)-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical R&D and scale-up work. All batches undergo comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.