Description

(R)-1-(Naphthalene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid CAS NO 1187928-75-1 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical specificity. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex, optically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecular architectures with defined stereochemistry.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Employed in scaling up synthetic routes for clinical trial material and commercial API manufacturing.
• Protease Inhibitor Research: The naphthalenesulfonyl-piperidine scaffold is relevant in the development of enzyme inhibitors.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control.

Basic Information

Product Name	(R)-1-(Naphthalene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid
CAS No.	1187928-75-1
Molecular Formula	C16H17NO4S
Molecular Weight	319.38 g/mol
Synonyms	(R)-1-(Naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid; (3R)-1-(2-Naphthylsulfonyl)-3-piperidinecarboxylic acid; (R)-1-(2-Naphthalenesulfonyl)piperidine-3-carboxylic acid; (R)-NSC 1187928; (R)-Piperidine-3-carboxylic acid, 1-(2-naphthalenesulfonyl)-; 1-(Naphthalene-2-sulfonyl)-D-pipecolic acid; (R)-1,2,3,4-Tetrahydro-1-(2-naphthalenesulfonyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-1-(Naphthalene-2-Sulfonyl)-Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.