Description

Ralinepag is a potent, orally active, non-prostanoid IP (prostacyclin) receptor agonist. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized in the development of novel therapeutics for pulmonary arterial hypertension (PAH) and related cardiovascular disorders. Researchers and manufacturers in the global pharmaceutical industry rely on high-purity Ralinepag CAS NO 1187856-49-0 for preclinical studies, formulation development, and clinical trial material production.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active pharmaceutical ingredient in the development of treatments for pulmonary arterial hypertension (PAH).
• Preclinical Research: Used in in vitro and in vivo studies to investigate IP receptor pharmacology, efficacy, and pharmacokinetics.
• Formulation Development: Essential for creating stable and bioavailable dosage forms, such as tablets or extended-release formulations.
• Clinical Trial Material (CTM): Supplied under GMP conditions for use in Phase I, II, and III clinical trials to establish safety and efficacy in humans.
• Reference Standard: Employed as a high-purity analytical standard for quality control, method development, and validation in analytical laboratories.
• Mechanistic Studies: Aids in cardiovascular research to understand the role of the prostacyclin pathway in vascular tone and remodeling.

Basic Information

Product Name	Ralinepag
CAS No.	1187856-49-0
Molecular Formula	C26H32N2O5
Molecular Weight	452.55 g/mol
Synonyms	Ralinepag; APD-811; 2-[[4-[(5,6-Diphenyl-2-pyrazinyl)oxy]-1-piperidinyl]carbonyl]benzoic Acid; ACT-293987; NS-304; UNII-6J3S4A3Q4D; Benzoic acid, 2-[[4-[(5,6-diphenyl-2-pyrazinyl)oxy]-1-piperidinyl]carbonyl]-
EINECS	Contact for details

Quality Control

Our Ralinepag is manufactured and tested to meet the stringent requirements of pharmaceutical development. Quality is assured through a comprehensive analytical program including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and residual solvent analysis. We support development from research to commercial scale with documentation suitable for regulatory filings. A detailed Certificate of Analysis (COA) is provided with each batch, and custom specifications can be developed to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.