Description

Lapatinib (4-Methylbenzenesulfonate) CAS NO 1187538-35-7 is a high-purity active pharmaceutical ingredient (API) and a key tyrosine kinase inhibitor. This compound is of critical importance for pharmaceutical research and development, particularly in the field of targeted cancer therapies. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on oncology drug discovery and formulation.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of anti-cancer medications.
• Oncology Research: Critical reference standard and biochemical tool for studying EGFR and HER2/neu (ErbB-2) tyrosine kinase pathways.
• Drug Development: Used in preclinical and clinical studies for the development of novel targeted cancer therapies.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Formulation Studies: Employed in the development of various dosage forms, including tablets and capsules.
• Biochemical Assays: Utilized in enzymatic assays to screen for kinase inhibitor activity and potency.

Basic Information

Product Name	Lapatinib (4-Methylbenzenesulfonate)
CAS No.	1187538-35-7
Molecular Formula	C₃₃H₃₄ClFN₄O₄S • C₇H₈O₃S
Molecular Weight	925.46 g/mol
Synonyms	Lapatinib ditosylate; Lapatinib Ditosylate; GW572016 ditosylate; Tykerb® (brand name salt form); N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine bis(4-methylbenzenesulfonate); Lapatinib ditosylate salt; Lapatinib tosylate
EINECS	Contact for details

Quality Control

Our Lapatinib (4-Methylbenzenesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial or client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.