Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-(1,1-Dimethylethyl)-5-Methyl- is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyridine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its unique molecular scaffold that enables the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• Oncology Drug Development: Used in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in creating novel molecules for neurological and psychiatric disorder research.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents and pesticides.
• Material Science Research: Can be utilized in the development of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-(1,1-Dimethylethyl)-5-Methyl-
CAS No.	1187448-81-2
Molecular Formula	C12H15ClN2
Molecular Weight	222.71 g/mol
Synonyms	4-Chloro-2-tert-butyl-5-methyl-1H-pyrrolo[2,3-b]pyridine; 2-tert-Butyl-4-chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-2-(tert-butyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-dimethylethyl)-5-methyl-; 4-Chloro-2-(tert-butyl)-5-methyl-7-azaindole; tert-Butyl 4-chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (related ester); CAS 1187448-81-2
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-(1,1-Dimethylethyl)-5-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment. We can support development with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.