Description

Gsk1120212 (Dmso Solvate) is a high-purity chemical reference standard, specifically formulated as a dimethyl sulfoxide solvate. This compound is critical for pharmaceutical research and development, particularly in the study of targeted kinase inhibition pathways. It is primarily utilized by researchers and manufacturers in the life sciences sector for preclinical studies, analytical method development, and as a key intermediate in active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical R&D Reference Standard: Serves as a certified material for analytical method validation, quality control, and bioactivity assays in drug discovery programs.
• Kinase Inhibitor Research: Used as a potent and selective tool compound in biochemical and cellular studies targeting specific signaling pathways.
• Preclinical Development: Employed in formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) modeling during early-stage drug development.
• Chemical Intermediate: Acts as a key synthetic precursor or intermediate in the scaled-up production of more complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional laboratories for fundamental research in oncology, immunology, and cellular biology.

Basic Information

Product Name	Gsk1120212 (Dmso Solvate)
CAS No.	1187431-43-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Trametinib DMSO solvate; GSK1120212 DMSO solvate; JTP-74057 DMSO solvate; MEK inhibitor GSK1120212 solvate; 2,3-Dihydro-2-[(3S)-3-[(3-fluorophenyl)methylamino]-2-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-1H-pyrrol-1-yl]-N-(2-hydroxy-1,1-dimethylethyl)-1H-isoindole-5-carboxamide compound with dimethyl sulfoxide
EINECS	Contact for details

Quality Control

Every batch of Gsk1120212 (Dmso Solvate) is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and traceable to certified reference materials. We adhere to cGMP guidelines for the production of materials intended for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits
DMSO Content (NMR/HPLC)	As per stoichiometry

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.