Description

5-Bromo-1-Methyl-2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrrolopyridine class of heterocyclic compounds. This compound matters as a critical building block for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas. It is needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile bromine substitution point.
• API Synthesis: Serves as a core scaffold in the multi-step synthesis of complex target molecules for preclinical and clinical trials.
• Oncology Drug Development: Employed in the construction of kinase inhibitors and other targeted cancer therapies.
• CNS Drug Discovery: Utilized as a building block for compounds intended to cross the blood-brain barrier.
• Chemical Biology: Acts as a probe or labeling agent in biochemical assays and target identification studies.
• Custom Synthesis: A starting material for contract manufacturing of proprietary compounds for biotechnology and pharmaceutical clients.

Basic Information

Product Name	5-Bromo-1-Methyl-2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1187421-56-2
Molecular Formula	C9H9BrN2
Molecular Weight	225.09 g/mol
Synonyms	5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2,3-dihydro-1-methyl-; 5-Bromo-1-methyl-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine; 1-Methyl-5-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-methyl-7-azaindoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Methyl-2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.