Description

tert-Butyl 4-(3-Bromo-5-Methylpyridin-2-Yl)Piperazine-1-Carboxylate CAS NO 1187386-02-2 is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and a substituted pyridine moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with improved potency and pharmacokinetic profiles.
• API Development: Serves as a versatile building block for constructing the core structure of potential new active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 4-(3-Bromo-5-Methylpyridin-2-Yl)Piperazine-1-Carboxylate
CAS No.	1187386-02-2
Molecular Formula	C15H22BrN3O2
Molecular Weight	356.26 g/mol
Synonyms	1-Boc-4-(3-bromo-5-methyl-2-pyridinyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(3-bromo-5-methylpyridin-2-yl)piperazine; tert-Butyl 4-(3-bromo-5-methyl-2-pyridinyl)-1-piperazinecarboxylate; 2-(4-Boc-piperazin-1-yl)-3-bromo-5-methylpyridine; BOC-4-(3-Bromo-5-Methyl-2-Pyridinyl)Piperazine; 1187386-02-2; 4-(3-Bromo-5-methylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Bromo-5-Methylpyridin-2-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.