Description

4-(3,4-Difluorobenzoyl)-2-Methylpyridine is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its precise molecular architecture, which is essential for constructing complex pharmacophores and functional materials. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, as well as by manufacturers of specialty chemicals and electronic materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other functional materials due to its conjugated system and fluorine substitution.
• Chemical Biology Probes: Utilized as a core structure for designing fluorescent tags or molecular probes to study biological processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4-(3,4-Difluorobenzoyl)-2-Methylpyridine
CAS No.	1187167-50-5
Molecular Formula	C13H9F2NO
Molecular Weight	233.21 g/mol
Synonyms	2-Methyl-4-(3,4-difluorobenzoyl)pyridine; 4-(3,4-Difluorobenzoyl)-2-picoline; 2-Picoline, 4-(3,4-difluorobenzoyl)-; 3,4-Difluorophenyl(2-methyl-4-pyridinyl)methanone; 4-(3,4-Difluorobenzoyl)-2-methylpyridine; (3,4-Difluorophenyl)(2-methylpyridin-4-yl)methanone; 2-Methyl-4-(3,4-difluorobenzoyl)pyridine; 1187167-50-5
EINECS	Contact for details

Quality Control

Every batch of 4-(3,4-Difluorobenzoyl)-2-Methylpyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.