Description

Lamivudine Triphosphate Ammonium Salt is a high-purity nucleotide analog triphosphate essential for biochemical and pharmaceutical research. This compound serves as a critical active metabolite and building block in the development of antiviral therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in virology, enzymology studies, and the synthesis of nucleotide-based prodrugs.

Application

• Biochemical Research: Used as a substrate for DNA polymerases in enzymatic studies and kinetic assays.
• Antiviral Drug Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs).
• Virology Studies: Employed in mechanistic studies to investigate the inhibition of viral reverse transcriptase, particularly for HIV and hepatitis B virus (HBV).
• Prodrug Synthesis: Acts as a crucial precursor in the development of lipophilic prodrugs designed to enhance cellular delivery of triphosphate analogs.
• Diagnostic Assay Development: Utilized in the formulation of controls and calibrators for molecular diagnostic tests targeting viral load quantification.

Basic Information

Product Name	Lamivudine Triphosphate Ammonium Salt
CAS No.	1187058-42-9
Molecular Formula	C8H19N4O12P3 • xNH3
Molecular Weight	Approx. 504.2 (Free acid) + (x*17.03)
Synonyms	(-)-2',3'-Dideoxy-3'-thiacytidine 5'-triphosphate ammonium salt; 3TC-TP ammonium salt; BCH-189 triphosphate ammonium salt; Lamivudine 5'-triphosphate ammonium salt; (2R,5S)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-methyl triphosphate ammonium salt; GR-109714X triphosphate ammonium salt; Epivir triphosphate ammonium salt
EINECS	Contact for details

Quality Control

Our Lamivudine Triphosphate Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity and impurity profiling. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Ammonium Content	Contact for details
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.