Description

3-(Boc-Amino)-5-Trifluoromethyl-Pyridine is a high-purity, protected amine building block essential for modern organic synthesis. This compound matters because it provides a versatile and reactive handle for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Peptide Mimetics & PROTACs: Serves as a crucial building block for constructing peptide-like structures and Proteolysis-Targeting Chimeras (PROTACs) due to its protected amino group.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Research: Incorporated into the backbone of polymers and advanced organic materials to impart specific electronic or solubility properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity, functionalized pyridine derivatives.

Basic Information

Product Name	3-(Boc-Amino)-5-Trifluoromethyl-Pyridine
CAS No.	1187055-61-3
Molecular Formula	C11H13F3N2O2
Molecular Weight	262.23 g/mol
Synonyms	tert-Butyl N-(5-(trifluoromethyl)pyridin-3-yl)carbamate; 5-(Trifluoromethyl)pyridin-3-amine, N-Boc-protected; 3-((tert-Butoxycarbonyl)amino)-5-(trifluoromethyl)pyridine; 3-Boc-amino-5-trifluoromethylpyridine; Boc-3-Amino-5-trifluoromethylpyridine; N-Boc-3-Amino-5-trifluoromethylpyridine; 3-Amino-5-trifluoromethylpyridine N-Boc derivative
EINECS	Contact for details

Quality Control

Our 3-(Boc-Amino)-5-Trifluoromethyl-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.