Description

5'-Azido-5'-Deoxy-5-Methyluridine is a chemically modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a versatile building block and a key precursor for the synthesis of novel nucleotide-based probes and therapeutic agents. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug discovery, and bioconjugation, where its unique azido functionality enables click chemistry applications for labeling and cross-linking.

Application

• Bioconjugation & Probe Synthesis: The azido group facilitates "click chemistry" reactions (e.g., CuAAC) for labeling biomolecules, creating fluorescent probes, or developing targeted drug delivery systems.
• Antiviral Research: Acts as a crucial intermediate in the design and synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Nucleic Acid Chemistry: Used in the development of modified oligonucleotides to study structure-function relationships, enhance stability, or introduce novel functionalities into DNA/RNA strands.
• Medicinal Chemistry: Serves as a key synthon for creating libraries of nucleoside analogs for high-throughput screening against various biological targets.
• Chemical Biology Tool Development: Employed in the creation of activity-based probes to study enzyme mechanisms, particularly those involving nucleotide metabolism.
• Academic & Industrial R&D: Fundamental research tool in universities and corporate R&D labs exploring novel therapeutic modalities and diagnostic agents.

Basic Information

Product Name	5'-Azido-5'-Deoxy-5-Methyluridine
CAS No.	1187022-65-6
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	5'-Azido-5'-deoxy-5-methyluridine; 5-Methyl-5'-azido-5'-deoxyuridine; 1-((2R,3S,5R)-5-Azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5'-N3-5-Methyluridine; Azidomethyluridine; 5'-Azido-5-methyl-2'-deoxyuridine (common misnomer); 5-Methyluridine-5'-azide
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxy-5-Methyluridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, NMR, and MS, are validated to provide reliable specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.