Description

3-Cyclopropyl-5-Nitro-1H-Pyrazolo[3,4-B]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for oncology, antiviral, and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Drug Discovery & Medicinal Chemistry: Used in research laboratories for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Agrochemical Research: Employed as a scaffold for developing novel pesticides and herbicides due to its bioactive pyrazolopyridine core.
• Material Science Precursor: Investigated for the synthesis of specialized ligands and organic electronic materials.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for custom synthesis and scale-up projects.

Basic Information

Product Name	3-Cyclopropyl-5-Nitro-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1186608-74-1
Molecular Formula	C9H8N4O2
Molecular Weight	204.19 g/mol
Synonyms	3-Cyclopropyl-5-nitro-1H-pyrazolo[3,4-b]pyridine; 5-Nitro-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 3-cyclopropyl-5-nitro-; Pyrazolo[3,4-b]pyridine, 3-cyclopropyl-5-nitro-; 1186608-74-1; 3-Cyclopropyl-5-nitro-1H-pyrazolo[3,4-b]pyridin; 3-Cyclopropyl-5-nitro-pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 3-Cyclopropyl-5-Nitro-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.