Description

2,6-Difluoro-n-(3-Methoxy-1H-Pyrazolo[3,4-B]Pyridin-5Yl)-3-(Propylsulfonamido)Benzamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry R&D: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Preclinical Development: Serves as a critical precursor for producing compounds for in vitro and in vivo biological testing.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of specialized, non-commercial APIs for clinical trials.
• Chemical Biology Probes: Can be utilized to develop tool compounds for studying specific biological pathways and target validation.
• Process Chemistry: Used in route scouting and scale-up studies for the development of efficient commercial manufacturing processes.

Basic Information

Product Name	2,6-Difluoro-n-(3-Methoxy-1H-Pyrazolo[3,4-B]Pyridin-5Yl)-3-(Propylsulfonamido)Benzamide
CAS No.	1186607-05-5
Molecular Formula	C19H18F2N6O4S
Molecular Weight	464.45 g/mol
Synonyms	2,6-Difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide; 2,6-Difluoro-3-[(propylsulfonyl)amino]-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide; 1186607-05-5; Benzamide, 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]-; 3-(N-Propylsulfamoyl)-2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-n-(3-Methoxy-1H-Pyrazolo[3,4-B]Pyridin-5Yl)-3-(Propylsulfonamido)Benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.