Description

2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Amine is a high-value, fluorinated heterocyclic building block essential for advanced pharmaceutical and agrochemical research. This compound's unique pyrrolopyridine scaffold, functionalized with a trifluoromethyl group and an amine, makes it a critical intermediate for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drugs, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Precursor: Serves as a specialty monomer or ligand in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fragment in fragment-based drug discovery (FBDD).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Amine
CAS No.	1186502-40-8
Molecular Formula	C8H6F3N3
Molecular Weight	201.15 g/mol
Synonyms	5-Amino-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 2-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-amine; 1H-Pyrrolo[2,3-b]pyridin-5-amine, 2-(trifluoromethyl)-; 1186502-40-8; 2-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-5-amine; 5-Amino-2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridin-5-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.