Description

4-Methoxy-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-C]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is of critical importance for its role as a key building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, especially within oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted small-molecule drugs, particularly protein kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved potency and selectivity.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Biochemical Probe Synthesis: Employed in creating labeled or modified compounds for studying biological pathways and target engagement in vitro.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	4-Methoxy-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-C]Pyridine
CAS No.	1186311-03-4
Molecular Formula	C18H30N2OSi
Molecular Weight	318.53 g/mol
Synonyms	1H-Pyrrolo[2,3-c]pyridine, 4-methoxy-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Methoxy-1-(triisopropylsilyl)-1H-pyrrolo[2,3-c]pyridine; TIPS-Protected 4-Methoxypyrrolo[2,3-c]pyridine; 1-(Triisopropylsilyl)-4-methoxy-1H-pyrrolo[2,3-c]pyridine; 4-Methoxy-1-(triisopropylsilyl)-7-azaindole; 7-Azaindole, 4-methoxy-1-(triisopropylsilyl)-
EINECS	Contact for details

Quality Control

Our 4-Methoxy-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-C]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with ICH guidelines and customer-specific requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.