Description

Mk-8353 CAS NO 1184173-73-6 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) compound, serving as a critical intermediate in advanced pharmaceutical research and development. Its primary value lies in enabling the synthesis of novel antiviral agents, particularly in the fight against resistant strains of HIV. This product is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on developing next-generation antiretroviral therapies and studying viral inhibition mechanisms.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Antiviral Research: Used as a reference standard and active scaffold in biochemical assays to study HIV-1 reverse transcriptase inhibition and mechanism of action.
• Medicinal Chemistry: Core structure for structure-activity relationship (SAR) studies and the development of new chemical entities with improved efficacy and resistance profiles.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies in drug discovery pipelines.
• Biochemical Tool Compound: Utilized in virology and molecular biology laboratories to probe viral replication pathways and identify new therapeutic targets.

Basic Information

Product Name	Mk-8353
CAS No.	1184173-73-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MK-8353; MK 8353; 1184173-73-6; (4-((4-(((2R,5S)-5-(Cyanomethyl)-2-methylpiperazin-1-yl)methyl)-3-fluorophenyl)amino)quinazolin-5-yl) dimethylphosphinate (IUPAC); Non-nucleoside reverse transcriptase inhibitor intermediate; NNRTI intermediate; Antiviral research compound
EINECS	Contact for details

Quality Control

Our Mk-8353 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.