Description

1-(4-Fluorophenyl)Cyclopropane-1-Carbonyl Chloride is a high-purity, reactive organic intermediate essential for advanced pharmaceutical and agrochemical synthesis. This compound serves as a critical building block for constructing complex molecules, enabling the introduction of the cyclopropane and fluorinated aryl motifs, which are key to modulating biological activity and physicochemical properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the production of active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorophenyl and cyclopropane groups enhance efficacy.
• Material Science Research: Serves as a precursor for novel polymers and liquid crystals, leveraging its rigid cyclopropane structure.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Fundamental reagent in medicinal chemistry and process chemistry laboratories for exploring new chemical entities and scalable routes.

Basic Information

Product Name	1-(4-Fluorophenyl)Cyclopropane-1-Carbonyl Chloride
CAS No.	1176030-00-4
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	1-(4-Fluorophenyl)cyclopropanecarbonyl chloride; 4-Fluorophenylcyclopropanecarbonyl chloride; 1-(p-Fluorophenyl)cyclopropanecarboxylic acid chloride; 1-(4-Fluorophenyl)cyclopropanecarboxylic acid chloride; p-Fluorophenylcyclopropanecarbonyl chloride; Cyclopropanecarbonyl chloride, 1-(4-fluorophenyl)-; 1-(4-Fluorophenyl)cyclopropanecarboxyl chloride
EINECS	Contact for details

Quality Control

Our production of 1-(4-Fluorophenyl)Cyclopropane-1-Carbonyl Chloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and away from incompatible materials. Keep the container tightly sealed when not in use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.